林炳文(Lin, Pin-Wen M.D.

外科學科、臨醫所   教授兼所長          電話內線:3643

                                                                        E-mail pinwen@mail.ncku.edu.tw

學歷:

台大醫學院學士

 

現職:

國立成功大學醫學系外科教授

國立成功大學醫學院臨床醫學研究所所長

國立成功大學醫學院附設醫院臨床醫學研究部主任

 

經歷:

國立成功大學醫學院臨床醫學研究所所長(20028~

國立成功大學醫學院附設醫院臨床醫學研究部主任(20028~

國立成功大學醫學院附設醫院外科部主任(19968~20027月)

國立成功大學醫學系外科主任                    19968~20027月)

國立成功大學醫學系外科教授                    19958~

國立成功大學醫學系外科副教授                19917~19957月)

國立成功大學醫學系外科講師                    19876~19916月)

Johns Hopkins Hospital外科研究員               19864~19875月)

國立成功大學醫學系外科助教                    19858~19863月)

國立臺大醫院外科住院醫師                        19808~19857月)

國立臺大醫院外科實習醫師                        19777~19786月)

 

專長:

肝膽胰外科

一般外科

 

研究興趣:

1.      器官再生及應用:肝臟是目前所知體內再生能力最強的器官,再生過程牽涉到肝細胞和間質細胞的作用,肝細胞本身的增殖,以及肝間質幹細胞的分化。肝功能衰竭是肝硬化患者的宿命,也是外科醫師切肝手術的夢饜,換肝手術是最後手段但時效上常援不濟急。藉由肝再生過程的研究,進一步了解肝細胞成長和肝間質細胞作用,以便於發展人工肝臟及肝衰竭細胞治療。

2.      肝癌手術後再發的基因探討:肝癌患者術後再發率很高,但這些再發性肝癌是否和原發性肝癌相同意義,既是多發性肝癌或是轉移癌仍未定論,目前,我們試圖以DNA microarrayproteomics的方法分析兩者差異性,期望藉由致癌機轉,進一步提供未來治療方向。

3.      胰臟癌的致癌機轉及治療:胰臟癌是最惡性的腫瘤之ㄧ,成大醫院是南部以手術治療胰臟癌的重要中心,目前我們正和嘉南區各大醫院組成聯合治療小組進行臨床治療。由於人種的不同,我們試圖將取得的癌組織進行基因分析,比較TNF-αIL-10的多型性變化,以及利用Ri-PCRquantative RCR分析VEGF-CVEGF-DVEGF-A和其轉移特性的相關研究。

執行中研究計畫:

一、        國科會計畫:

*胰十二指腸切除術前後病人之膽汁與胰液之研究:腫瘤標記、細胞學、生物學和終端酉每 活性之研究

*胰十二指腸切除術後胃排空及幽門功能荷爾蒙之研究:傳統性與幽門保留胰十二指腸切除術之比較

二、        嘉南地區跨院研究計畫:

Down staging of unresectable pancreatic cancer with chemoradiation therapy

Postoperative adjuvant chemotherapy for resectable pancreatic cancer

近五年代表作:

1.    Lin PW, Shan YS, Lin YJ. Prospective randomized trial of standard vs pylorus-preserving pancreaticoduodenectomy for carcinoma of the head of the pancreas. Br. J. Surg 2003. (Submitted)

2.    Shan YS, Sy ED, Tsai MJ, Tang LY, Li PS, Li PS, Lin PW*. Prophylactic use of somatostatin increases the incidence of delayed gastric emptying: Involvement of reduction of motilin in post pylorus-preserving pancreaticoduodenectomy. Arch. J. Surg. 2003 (Submitted) (correspondence)

3.    Shan YS, Hsu HP, Hsieh YH, Sy ED, Lee JQ, PW Lin*.The significance of intraoperative peritoneal culture of fungus in perforated peptic ulcer. Br. J. Surg 2003; 90: 1215-9.  (correspondence)

4.    Shan YS, Sy, ED, PW Lin*. Role of somatostatin in the prevention of pancreatic stump related morbidity following elective pancreaticoduodenectomy in high risk patients and elimination of surgeon related factor: A prospective, randomized, controlled trial. World Journal of Surgery 2003; 27: 709-14.

5.    Young KC, Lin PW, Hsiao WC, Chang TT, Chang YC, Wu WL. Variation of hepatitis C virus load, hypervariable region 1 quasispecies and CD81 hepatocyte expression in hepatocellular carcinoma and adjacent non-cancerous liver. Journal of Medical Variology 2002; 68: 188-196.

6.    Wang YL, Sheu BS, Yang HB, Lin PW, Chang YC. Overexpression of c-erb-B2 proteins in tumor and non-tumor parts of gastric adenocarcinoma---Emphasis on its relation to H. pylori infection and clinicohistological characteristics. Hepato-Gastroenterology 2002; 49: 1172-6.

7.    Sheu BS, Yang HB, Wang YL, Kao AW, Chuang CH, Lin PW, Chang YC. Stool antigen assay to screen H. pylori infection and to assess the success of 3-day and 7-day eradication therapy in the patients with partial gastrectomy. Helicobacter 2002; 7: 199-204.

8.    Yao WJ, Wang ST, Chow NH, Chang TS, Lin PW, Tu DG. Serum Tissue polypeptide specific antigen as a noninvasive prognostic indicator for early recurrence of hepatocellular carcinoma after curative resection. Cancer 2002; 95: 112-8.

9.    Chen MJ, Tai YS, Chang YC, Shan YS, Lin YJ, Lin PW*. Percutaneous transhepatic gallbladder drainage followed by laparoscopic cholecystectomy for acute cholecystitis. Formosan J. Surg 2002; 35: 82-6. (correspondence)

10. Shan YS, Sy ED, Lin PW*. Nonsurgical treatment for the main pancreatic duct transection with pseudocyst in blunt abdominal injury. Pancreas 2002; 25: 210-5 (correspondence)

11. Shan YS, Sy ED, Tsai HM, Lin PW*. Annular pancreas with obstructive jaundice. Beware of underlying neoplasms. Pancreas 2002; 25: 314-6 (correspondence).

12. Shan YS, Chang SS, Lin PW*. Somatostatin in the prevention of surgical complications following elective pancreaticoduodenectomy. A prospective, randomized, controlled trial. J HBP Surg 2001; 8 supply1: 31. (correspondence)

13. Yao WJ, Chang TT, Wang ST, Chow NH, Lin PW, Chang YC, Tu DG, Chiu NT. Clinicopathologic correlation of serum tissue polypeptide specific antigen in hepatocellular carcinoma. Oncology 2001; 61: 64-70.

14. Shan YS, Sy ED, Lin PW*. Chronic hemosccus pancreaticus. A rare complication of pancreatic microcystic adenoma successfully treated with Whipple’s procedure. Pancreas 2000; 200: 416-8. (correspondence)

15. Shan YS, Sy ED, Lin PW*. Surgical resection of isolated pancreatic tuberculosis presenting as obstructive jaundice. Pancreas 2000; 21: 100-1. (correspondence)

16. Hsiao WC, Young KC, Wang ST, Lin PW*. Incisional hernia after laparotomy: Prospective randomized comparison between early and late absorbable suture materials. World Journal of Surgery 2000; 24: 747-752 (correspondence)

17. Tai YS, Lin PW*. Laparoscopic ventral and incisional hernia repair: A preliminary report. Formosan J Surg 2000; 33: 8-13. (correspondence)

18. Huang SM, Shan YS, Sy ED, Lin PW. Superior mesentery artery syndrome in post-spinal cord injury masquerading as peptic ulcer disease. Formosan J. Surg 2000; 33: 229-33.

19. Sheu BS, Lee SC, Lin PW, Wang ST, Chang YC, Yang HB, Chuang CH, Lin XZ. 13Carbon urea breath test is not as accurate as endoscopy to detect Helicobacter pylori after gastrectomy. Gastrointest Endosc 2000; 51: 670-5.

20. Lin PW, Lin YJ. Complications after pancreaticoduodenectomy: A prospective randomized comparison between PPPD and Whipple procedure. Br. J. S. 1999; 86:603-607.

21. Shan YS, Sy ED, Cheng CJ. Duodenal obstruction secondary to phytobezoar in a child. Surgically removed Via gastrostomy. Formoasn J Surgery 1999; 32: 28-32.

22. Lee WY, Jin YT, Chang TW, Lin PW, Su IJ. Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters. Histopathology 1999; 34: 106-112.